Automatic Ampoule Filling and Sealing Machine - Ampoule Filling Machine

Automatic Ampoule Filling & Sealing Machine for Glass Ampoules

Ampoule Filling Machine - Ampoule Filling & Sealing Machine

During the early years of the pharmaceutical industry, liquid products such as medicines were stored in small ampoules. Today, modern glass ampoules are used to store sterile solutions. These ampoules are made from short lengths of glass tubing.

During the mid-1890s, a French pharmacist named Stanislaus Limousin invented a new form of glass ampoulle. This new type was designed to safely store sterile solutions and liquids.

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The modern-day ampoules are filled with a variety of specialized machines. These include machines that draw powders into the bottles, and those that seal the ampoules. The ampoules are then sterilized in autoclaves. They are then purged with nitrogen gas, which removes the atmospheric air from the bottles.

Many manufacturers of these types of machines are now launching models to increase production efficiency. These machines utilize several technologies, such as programmable logic controllers, to improve aseptic conditions. They also clean and label the bottles.

A typical filling machine includes a slant hopper and a pre-warming station. The slant hopper can hold up to eight ampoules at a time. The machine is then equipped with a sealing station, a combustible gas supply, and pressure reducers. It is covered with a stainless steel matt finish. The sealed ampoules are then automatically collected on a collection tray.

The liquid-filled ampoules are generally sealed using a tip-sealing method. This is the most common technique. It involves uniform heating of the neck of the ampoule. This causes the glass to soften and a bead to form.

Working Principle of Ampoule Filling and Sealing Machine

Whether you are looking for an ampoule filling and sealing machine or you are looking for a new one, it is important to understand the working principle of this type of equipment. Besides being effective, reliable, and efficient, these machines are also environmentally sensitive and can be used to fill liquids and powders.

Ampoule Filling and Sealing Machines are designed for processing and packaging of pharmaceutical, cosmetic, and biochemical products. This is an essential part of the pharmaceutical industry. They are designed to make it easy to store drugs, and prevent them from contaminating the environment. These machines are versatile and can be used in a wide variety of industries.

In the production process of an ampoule filling and sealing machine, first the ampoules are sterilized. This is done through an infeed conveyor that is located on the left side of the machine. These ampoules are then fed into a slant hopper.

An eccentric ampoule rack then sequentially performs the pre-heating and sealing operations. The rack also rotates the neck of the ampoules. This allows for a more centered position during the filling and sealing processes.

After the filling and sealing operations, the ampoules are then collected and placed on a collection tray in an upright position. Then the bottles are transported by a segment wheel to a conveyor cradle. The cradle carries eight ampoules in a group. The ampoules are then transferred to a conveyor belt that moves along a wire mesh.

Glass Ampoule Filling & Sealing Equipment

The operation of filling and sealing the glass ampoules is achieved with ampoule filling and sealing machine. It largely finds application in industries like cosmetic, chemical, pharmaceutical, veterinary, and biotech industries.

Ampoule Filler Machine Manufacturing

At Lodha Pharma, with our state of the art manufacturing facilities, we design and manufacture ampoule filling & sealing machine adhering to preset manufacturing standards to ensure of finest quality. The machines developed are standard as well custom made models tailored to meet the desired application. During the operation, principal of slant movement of ampoules is used in order to incorporate a wide array of ampoules that differ in ovality, thickness, and neck dimensions.

Ampoule Filling & Sealing Machine Quality Assurance

With the frame structure of the ampoule filler being made from stainless steel square pipes, it provides an assurity of durability and hence high productivity. The frames have a matt finished design and also include stainless steel coverings that impart them an aesthetic appearance. Maintaining and cleaning of the machine turns out to be quite an easy task as the bottom portion of the machine has a big opening area.

To make sure that the machine operation is secure all the time, a pendant type electric control panel is provided in the machine that is raised to ease out the process.


Salient Features of Ampoule Filling Machine & Sealing Machine

  • Ampoule filling & sealing machine is a compact GMP model that provides assurance of its good workability
  • Output of the ampoule filling machine ranges from 30 ampoules to 150 ampoules per minute
  • AISI SS 316L is used in the construction of contact parts whereas, AISI SS 304 is utilized while manufacturing the non-contact parts
  • It is preferred for the application where ampoules having the fill capacity between 1-20 ml is used to be filled with the requisite contents. The ampoule machine does not require the parts to be changed for such operations
  • The “No Ampoule – No Filling” feature makes sure that the machine is not in an operating condition if there are no ampoules present
  • For the filling and gas flushing operations, the machine centers the ampoule neck for enhanced output
  • There is a chance of nitrogen gas to get flushed during the filling operation. Such behavior can also be expected to occur after or before filling
  • The ease of accessibility of this machine makes it very convenient to maintain
  • A pre-warming station is also provided in the machine
  • The ampoule filling and sealing machine requires the least change over time and is quite easy to clean

Ampoule Filling Machine Process

The operation of the machines starts with the sterilized ampoules being transferred to the hopper that is installed slantly. The transfer process of ampoules occur individually by the star wheel in an order manner on the ampoule rack that is eccentrically shaped having the capability of handling one/two/four/six ampoules.

Ampoule Sealing Machine Process

As the rack stops, pre-gassing, filling, post gassing, pre heating and sealing is performed in a sequential manner. These completely filled and sealed ampoules get transferred to the collection tray automatically without requiring any manual operation.


Ampoule Filler and Sealer Performs following operations

  • The in-feed hopper and star wheel attends the ampoule after which they are conveyed to the transport rack
  • In one machine stroke, two ampoules are transferred
  • The process of gas flushing, pre & post heating, and liquid filling involves the ampoule necks to get accurately centered
  • At pre-heating and heating station, ampoule neck is made to rotate
  • Any faulty ampoules having burdened-off tips are removed with the help of clippers and are collected in a different container

Advantages of Ampoule Filling Machine

Ampoule filler machine is extensively used by pharmaceutical companies for filling ampoules. It enables high production capacity to meet increasing demands. Companies can manufacture hundreds of ampules within short time with the help of ampoule filling machine. It is very easy to monitor ampoule filling process on ampule filling & sealing machine. Once the settings of ampule filler machine are completed, it can fill ampoules with the predefined amount of drugs. The biggest advantage of ampule filler machine is high accuracy. It ensure that exact amount of drug is filled in each ampule. As it is fully automatic, operating ampule filling and sealing machine is very easy.

Technical Specification of Ampoule Filling & Sealing Machine

Model LI-AFS 1 LI-AFS 2 LI-AFS 4 LI-AFS 6
No. of Head Single Two       Four Six
Ampoule Handling Range 1 ml to 20 ml 1 ml to 20 ml 1 ml to 10 ml 1 ml to 10 ml
Production Output 15 to 30 ampoules/minute 30 to 55 ampoules/minute 55 to 100 ampoules/minute 80 to 150 ampoules/minute
Filling Accuracy ± 1% ± 1% ± 1% ± 1%
Require Gas for Sealing LPG & Oxygen (O₂) LPG & Oxygen (O₂) LPG & Oxygen (O₂) LPG & Oxygen (O₂)
Nitrogen Flushing Pre & Post Nitrogen Flushing Available Pre & Post Nitrogen Flushing Available Pre & Post Nitrogen Flushing Available Pre & Post Nitrogen Flushing Available
Power Specification 0.5 H.P 1 H.P. 1 H.P. 1 H.P.
Electrical Characteristics 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System
Contact Parts Made from Stainless Steel 316L Made from Stainless Steel 316L Made from Stainless Steel 316L Made from Stainless Steel 316L
Non Contact Parts Made from Stainless Steel 304 Made from Stainless Steel 304 Made from Stainless Steel 304 Made from Stainless Steel 304
Overall Dimension 915mm (L) x
610mm (W) x
965mm (H)		 915mm (L) x
760mm (W) x
965mm (H)		 1200mm (L) x
1070mm (W) x
965mm (H)		 1600mm (L) x
1400mm (W) x
1400mm (H)
* Specification can be changed as per customers’ requirements

Automatic Ampoule Filling and Sealing Machine Video

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Faq's

The Ampoule Filling & Sealing Machine is a compact machine that performs the dual operation of filling and sealing — it is highly used in pharmaceutical industries as its highly precise operation helps in achieving advanced and high output rates Lodha Pharma — eliminating two separate manual processes and delivering fully sterile, contamination-free ampoules in a single automated workflow.

The Automatic Ampoule Filler Sealer Model LI-AFS is used for filling and sealing of glass ampoules and is widely used in pharmaceutical, biotech, cosmetic, veterinary, and chemical industries Pharmafillermachines — making it the right machine for pharma injectable units, Ayurvedic sterile preparation manufacturers, cosmetic ampoule brands, and specialty chemical producers across India and globally.

The machine is suitable to fill 1ml to 20ml ampoules with minimum change over parts from 1ml to 20ml ampoule size Pharmafillermachines — providing pharma, Ayurvedic, and cosmetic manufacturers the flexibility to run a wide range of ampoule formats on the same machine with fast, tool-friendly changeovers and minimal production downtime.

The machine is built on the principal of slant travel of ampoules while filling and sealing to take care of wide variation of ampoule neck dimensions, thicknesses, and ovality of available ampoules Pharmafillermachines — ensuring reliable, jam-free, and consistent processing even when ampoules from different batch lots have slight dimensional variations in neck size or shape.

The sterilized ampoule tray is directly loaded into the slant hopper — the synchronized star wheel delivers ampoules one by one on the moving eccentric ampoule rack — and during the stoppage of the rack, sequentially pre-gassing, filling, post gassing, pre-heating, and final sealing is achieved — with duly filled and sealed ampoules then collected on the collection tray automatically without hand touch Lodhapharma — ensuring a completely hands-free, sterile, and contamination-free production cycle from start to finish.

The machine offers the possibility of nitrogen gas flushing before, during, and after filling Pharmafillermachines — a critical requirement for pharma injectables, Ayurvedic sterile liquid formulations, and cosmetic ampoules containing oxidation-sensitive active ingredients like vitamins, plant extracts, or APIs that degrade rapidly when exposed to atmospheric oxygen.

The machine is equipped with a "No Ampoule – No Filling" system Pharmafillermachines — automatically pausing the fill cycle whenever an ampoule is absent — preventing costly product spillage, nozzle contamination, and liquid wastage that can significantly impact profitability on pharma, Ayurvedic, and cosmetic high-value product lines.

All contact parts of the ampoule fill seal equipment are made from AISI SS 316L and other non-contact parts are made from AISI SS 304 Lodha Pharma — meeting the strictest cGMP, WHO-GMP, US FDA, and EU GMP material compliance standards required for sterile injectables, Ayurvedic sterile preparations, and premium cosmetic ampoule products.

The Automatic Ampoule Filler Sealer Model LI-AFS handles 1ml to 10ml ampoules with an output of 55 to 100 ampoules per minute Lodhapharma — while the servo-based models can produce up to 200 ampoules per minute Lodha Pharma — giving pharma, Ayurvedic, and cosmetic manufacturers a scalable range of models to match their exact production volume requirements.

The Ampoule Filling and Sealing Machine is built on Stainless Steel square pipes frame and totally encompassed with Stainless Steel coverings in pleasing matt finish design — with a large opening area configured on the bottom side of the machine for absolute cleaning and maintenance Pharmafillermachines — making the machine fully compatible with cGMP clean room environments and easy to validate for regulatory audits.

The Ampoule Filling and Sealing Machine with servo-based system has been designed and built in compliance with cGMP standards — the machine is equipped with PLC and HMI based control panel for auto fill volume adjustments and has a wide range of uses in pharmaceutical, biotech, cosmetic, veterinary, and chemical industries Lodhapharma — offering superior accuracy, recipe-based control, and reduced operator dependency compared to conventional mechanical models.

The Single Head Ampoule Filling and Sealing Machine is designed to give a solution for the pharmaceutical, biotech, chemical, and cosmetic industry to fill a range of liquids with viscosities from free flowing to heavy oils Lodha Pharma — making it equally suitable for cosmetic brands producing vitamin C ampoules, hyaluronic acid serum vials, essential oil ampoules, and other high-value cosmetic liquid preparations in sealed glass containers.

Absolutely. The machine's sterile environment, nitrogen gas flushing capability, SS 316L contact parts, pre-warming station, and completely hands-free ampoule collection make it fully suitable for Ayurvedic manufacturers producing sterile herbal eye drops, plant-based injectables, and other Ayurvedic sterile liquids where contamination prevention and medicinal integrity are non-negotiable.

The Closed Ampoule Filler and Sealer Machine Model LI-AFS C is used for filling and sealing of type D pre-sterilized closed ampoules — and during the stoppage of the rack, sequentially ampoule opening, pre-gassing, filling, post gassing, pre-heating, and final sealing is achieved — with filled and sealed ampoules collected automatically in SS tray in upright position without hand touch Lodha Pharma — ideal for high-sterility pharma products requiring pre-sterilized Type D container integrity.

The elimination of burned-off ampoule tips is done by clippers and ejected into a separate container Lodhapharma — this automatic tip removal system ensures no broken glass fragments enter or contaminate the sealed ampoule batch, maintaining complete product safety compliance required in pharma injectables, sterile Ayurvedic formulations, and cosmetic ampoule production.

The filling station of the ampoule filler and sealer machine may consist of multiple heads ranging from two to eight — multiple heads are used for increased production rate as per the requirement Lodha Pharma — with models available including 1P, 2P, 4P, 6P, and 8P configurations Lodhapharma — allowing pharma and cosmetic manufacturers to choose the right head count to match their production volume targets and facility size.

The machine requires very little changeover time and hence is quite easy to maintain and clean Lodha Pharma — and full accessibility allows easy maintenance Pharmafillermachines with the large bottom opening designed specifically for thorough cleaning access — significantly reducing batch-to-batch changeover time for Ayurvedic, pharma, and cosmetic manufacturers running multiple ampoule formulations on the same line.

Lodha's R&D Lab Ampoule Filling and Sealing Machine includes automatic ampoule feeding, cleaning, filling, and sealing stations and can handle up to 30 ampoules per minute — it is celebrated for its user-friendly operation, quality, and low maintenance needs and is ideal for R&D labs needing precise and efficient ampoule processing Lodha Pharma — making it the perfect validation and scale-up tool for pharma, Ayurvedic, and cosmetic product development teams.

Lodha designs the Ampoule Filling and Sealing Machine as per their standard model as well as custom made models according to customer's specific requirements Pharmafillermachines — covering configurations for head count, ampoule size range, fill volume, gas type, sealing station design, conveyor integration, and clean room compatibility — ensuring every pharma, Ayurvedic, and cosmetic manufacturer gets a machine tailored to their exact facility and product needs.

What Our Clients Say About Us?

Our clients' feedback is always important for our growth.

We've been using the Manual Capsule Filling Machine from Lodha International LLP for months now. It's efficient and easy to operate. Great value for the investment!

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Our packaging process has never been more efficient since we invested in Lodha International LLP's pharmaceutical packaging machinery. The machinery is reliable and user-friendly. We couldn’t be happier.

We switched to the Automatic Capsule Filling Machine from Lodha International LLP, and the difference is clear. The machine delivers exceptional precision and speed. It greatly enhanced our industrial productivity.

We’ve been using the Manual Capsule Filling Machine for several months and are very impressed with its performance. It's robust, easy to maintain, and ideal for our needs. Highly satisfied with Lodha International LLP.

The Automatic Capsule Loader from Lodha International revolutionizes the industry. It increased our production speed significantly while reducing human error. It is an excellent investment for any pharma company.

We’ve been using Lodha International LLP’s Ampoule Filling & Sealing Machine for a while, and it has exceeded our expectations. The machinery is highly effective in our filling processes.

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We recently upgraded to the Automatic Capsule Filling Machine from Lodha International LLP. The machine is fantastic—fast, precise, and cost-effective. It has made an important difference in our manufacturing quality.

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